How Treg cells lose FOXP3
نویسندگان
چکیده
منابع مشابه
FOXP3+ Treg Cells and Gender Bias in Autoimmune Diseases
CD4(+)CD25(+) regulatory T (Treg) cells play a pivotal role in the maintenance of immune homeostasis, where the X-linked master transcription factor forkhead box P3 (FOXP3) determines Treg cell development and function. Genetic deficiency of foxp3 induces dysfunction of Treg cells and immuno-dysregulation, polyendocrinopathy, enteropathy, and X-linked syndrome in humans. Functionally deficient ...
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Th17 and regulatory T (Treg) cells are integral in maintaining immune homeostasis and Th17-Treg imbalance is associated with inflammatory immunosuppression in cancer. Here we show that Th17 cells are a source of tumour-induced Foxp3+ cells. In addition to natural (n)Treg and induced (i)Treg cells that develop from naive precursors, suppressive IL-17A+Foxp3+ and ex-Th17 Foxp3+ cells are converte...
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ژورنال
عنوان ژورنال: Nature Reviews Rheumatology
سال: 2019
ISSN: 1759-4790,1759-4804
DOI: 10.1038/s41584-019-0171-4